Scientific Publications

• Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine- a phase I-II clinical trial


• Nicotinamide Modulates Ex-Vivo Expansion of Cord Blood Derived CD34+ Cells Cultured with Cytokines and Promotes Their Homing and Engraftment in SCID Mice


• Antagonists to Retinoid Receptors Down-Regulate CD38 Expression and Inhibit In Vitro Differentiation of Cord Blood Derived CD34+ Cells


• NICOTINAMIDE ATTENUATES IN VITRO DIFFERENTIATION AND ELEVATES BONE MARROW HOMING POTENTIAL OF CULTURED CD34+ CELLS


• Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells


• Cellular copper content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells. Br J Haematol. 2002;116:655-661


• Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34(+) cells and increases their engraftment potential in NOD/SCID mice. Exp Hematol. 2004;32:547-55


• Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Cytotherapy 2004;6:344-55


• The Effect of Tetraethylenepentamine, a Synthetic Copper Chelating Polyamine, on Expression of CD34 and CD38 Antigens on Normal and Leukemic Hematopoietic Cells Leukemia & Lymphoma, March 2004 Vol. 45 (3), pp. 583–589


• Nicotinamide, a Specific Inhibitor of NAD(+)-Dependent ADP-ribosyl Transferases Promotes Ex-Vivo Expansion of Early Subsets of Hemopoietic CD34+ Cells


• Ex-vivo Expanded Human Bone Marrow-Derived CD133+ Cells Improve Cardiac Function in Rats With Acute Myocardial Infarction